The focus of the research conducted at the LYric is based on three research programs:
- Fundamental research
- Transfer research, at the interface between the other research programs
- Clinical research (treatment protocols for patients)
Two of these research programs are conducted in collaboration with the CRCL and the third one is a joint research program in collaboration with the team of Michel Rivoire from the Experimental Surgery Institute (ICE) of LabTau, and the team of David Sarrut from the Creatis Laboratory (CNRS UMR 5220 – Inserm U1044 – Université Lyon 1).
These research programs meet the main aim of the LYric: the development of personalized treatments through targeted therapies.
Governance & management
The LYric is supported by the Centre Léon Bérard (Lyon Comprehensive Cancer Centre) and the Hospices Civils de Lyon (Lyon University Hospitals), through the GCS-LCU structure (Groupement de Coopération Sanitaire Lyon Cancérologie Universitaire).
The management team includes:
- The Director, Professor Jean-Yves Blay, Director of the Centre Léon Bérard
- 2 deputy directors :
- Professor Alain Puisieux (Director of the Cancer Research Center of Lyon (CRCL))
- Professor Charles Dumontet (Head of the Scientific Research Commission of the Hospices Civils de Lyon),
- The coordinator: Marina Rousseau-Tsangaris, General Secretary for Research at the Centre Léon Bérard.
- Scientific animation: Séverine Tabone-Eglinger
The general organization of the LYric is divided into workpackages in order to handle the specific features of the programs.
Each workpackage is managed by a medical doctor and a research scientist to allow interactions that will take into account the 2 different aspects of research. Furthermore, there is a workpackage for each research program. The research program relies on technological platforms and support workpackages (WP1, WP6, WP7 and WP8), dedicated to boost the different types of research.
In 2010, the French National Cancer Institute (INCa) launched a call for proposals for the creation of Integrated Cancer Research Sites (SIRIC), as part of the France’s Second National Cancer Research Plan (2009-2013).
Two applications out of the 12 sent by the different research sites were awarded a SIRIC label in June 2011, namely the:
- The SIRIC of the Curie Institute in Paris
- The LYric, the integrated research Site of Lyon, supported by the “Centre Léon Bérard” (Lyon Comprehensive Cancer Centre) and the “Hospices Civils de Lyon” (Lyon University Hospitals) in the GCS-LCU structure.
By awarding the SIRIC label, the INCa has two objectives:
- First, the INCa wants to structure the SIRIC and set up multidisciplinary organizations, enabling them to be more efficient. Patients will, thus, benefit more rapidly from the advances in cancer research and from technological innovations.These challenging issues led the INCa to create a new call for proposals in 2011, and 6 new sites were awarded a SIRIC label in 2012.
- Second, to implement as early as possible a research continuum from fundamental research to the patient, and to develop cross-disciplinary approaches, to transfer the knowledge and results obtained by fundamental research, to boost their transfer and the integration of multidisciplinary research for an global follow-up of the patient and his/her disease.